A large African bovid, Syncerus caffer.
Any of the Old World mammals of the family Bovidae, such as the Cape buffalo, Syncerus caffer, or the water buffalo Bubalus bubalis.
A related North American animal, the American bison, Bison bison.
The buffalo fish (Ictiobus spp.).
A nickel.
To outwit, confuse, deceive, or intimidate.
To hunt buffalo.