To make bitter or sour.
To exasperate; to irritate.
Embittered; having a sour disposition or nature.
To make someone feel bad emotionally.
To cause to fall down, e.g. in an accident.
To reduce.
To make something, especially something flying, fall to the ground, usually by firing a weapon of some kind.
To make a ruler lose their position of power.
To cause an opponent to fall after a tackle.
To humble.