anguish vs irritate

anguish

verb
  • To cause to suffer pain. 

  • To suffer pain. 

noun
  • Extreme pain, either of body or mind; excruciating distress. 

irritate

verb
  • To induce pain in (all or part of a body or organism). 

  • To cause or induce displeasure or irritation. 

  • To provoke impatience, anger, or displeasure in. 

How often have the words anguish and irritate occurred in a corpus of books? (source: Google Ngram Viewer )