Extreme pain, either of body or mind; excruciating distress.
To cause to suffer pain.
To suffer pain.
A state of restlessness and agitation, often accompanied by a distressing sense of oppression or tightness in the stomach.
An unpleasant state of mental uneasiness, nervousness, apprehension and obsession or concern about some uncertain event.
An uneasy or distressing desire (for something).