An uneasy or distressing desire (for something).
An unpleasant state of mental uneasiness, nervousness, apprehension and obsession or concern about some uncertain event.
A state of restlessness and agitation, often accompanied by a distressing sense of oppression or tightness in the stomach.
Difficulty or trouble; hard times.
A burden, a source of difficulty that could impose a barrier.
To treat (a person) badly; to subject to hardships.