Major, important.
Of or relating to an artery.
A through road.
Foremost; first or highest in quality or degree.
Most ancient.
The champion team of a particular season (especially as used in Australian rules football).
The government leader in a legislative congress or leader of a government-level administrative body; the head of government.
The leader of a state or provincial government and cabinet.
The prime minister.
The first lieutenant or other second-in-command officer of a ship.
To perform, display or exhibit for the first time.
To govern in the role of premier.