Used to indicate a change of subject.
Used at the end of a question for emphasis, or to direct the conversation to something of more broad importance (compare with more to the point).
Regardless; anyhow.
Used to indicate that a statement explains or supports a previous statement. See anyhow and at least.
Used other than figuratively or idiomatically: see as, it, is.
In the actual circumstances (and often contrary to expectations).
Already; without adding further difficulty or complexity.