to attack someone (especially verbally) unfairly in a deceitful, underhand, or treacherous manner, especially when they're not present in the place or situation that it happens. (as if stabbing them in the back). See backbite.
To betray or go back on.
To cross twice in hybridization, as (A × B) × (C × D); for example, in commercial hybrid seed corn, A through D are classically inbreds, and their grandoffspring is the seed for sale.