A rude, obnoxious, or contemptible person.
A contemptible or unfashionable person.
A person convicted of a crime, especially more than once.
One who or that which loses something, such as extra weight, car keys, etc.
A person who is frequently unsuccessful in life.
A person who loses; one who fails to win or thrive.
A losing proposition, one that is likely to lose or already has lost (such as a losing bet or, analogously, a predictably fruitless task or errand).
Something of poor quality.