To beat really badly.
To hit hard .
To make (someone) sleepy or delirious, to put into a stupor .
To become exhausted, sleepy or delirious.
The feeling of a drug taking hold.
An unfavorable card or token, or undesirable or worthless item used as a prize in a contest or game show (such as Let's Make a Deal).
A cigarette hand-rolled from tobacco and cannabis.