A hospital, especially a lunatic asylum.
A flea-infested hotel, lodging-house etc.
A prison.
A cheap and dirty cinema.
Crazy, insane.
A large medical facility, usually in a building with multiple floors, where seriously ill or injured patients are given extensive medical and/or surgical treatment.
A building founded for the long-term care of its residents, such as an almshouse. The residents may have no physical ailments, but simply need financial support.