A hardened area of the skin (especially on the foot or hand) caused by repeated friction, wear or use.
A shining area on the frons of many species of Tabanomorpha (horse flies and relatives).
The material of repair in fractures of bone; a substance exuded at the site of fracture, which is at first soft or cartilaginous in consistency, but is ultimately converted into true bone and unites the fragments into a single piece.
The new formation over the end of a cutting, before it puts out rootlets.
To form such hardened tissue.
Something causing disease or injury to the body or bodily processes; the injury so caused.
Something that causes offence (for example, by being of an unacceptable quality).
Action or form of speech deliberately intended to be rude; (countable) a particular act or statement having this effect.
To be insensitive, insolent, or rude to (somebody); to affront or demean (someone).