Being very important, or key to something.
Having or containing the centre of something.
Being in the centre.
Exerting its action towards the peripheral organs.
centre
Having a relevance to the matter at hand: pertinent, relevant.
Directed negatively at a person or topic.
That has a named, but otherwise arbitrary, point (called the basepoint) that remains unchanged during subsequent discussion and is kept track of during all operations.
Sharp, barbed; not dull.
In animals, having a coat pattern with points, that is, darkening of the extremities.