Distress of mind caused by a failure of aims or plans, want of appreciation, mistakes etc; vexation or mortification.
A type of leather or skin with a rough surface.
To bother or vex; to mortify.
The state of being irritated
A things or person that annoys
A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.
The act of irritating or annoying
a state of inflammation or painful reaction to allergy or cell-lining damage.