To fuck (something) up, to make a total mess of.
A chaotic situation where everything seems to go wrong. It is often caused by incompetence, communication failure, or a complex environment.
To ruin utterly and catastrophically, to cause to end in disaster.
The aftermath of a train crash.
A disaster, especially one which is large in scale and readily seen by public observers.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.