A traumatic or stressful change in a person's life.
A crucial or decisive point or situation; a turning point.
A sudden change in the course of a disease, usually at which point the patient is expected to either recover or die.
A point in a drama at which a conflict reaches a peak before being resolved.
An unstable situation, in political, social, economic or military affairs, especially one involving an impending abrupt change.
The inability to adapt oneself to the needs of others, or to the stresses of normal life.
A poor or faulty adjustment, especially of a mechanism.