A strike or blow that leads to death, especially a coup de grace.
Something that prevents the completion, or ends the existence, of a project etc.; a fatal setback.
The act or instance of being defeated, of being overcome or vanquished; a loss.
Frustration (by prevention of success), stymieing; (law) nullification.
The act or instance of defeating, of overcoming, vanquishing.
To nullify
To prevent (something) from being achieved.
To reduce, to nothing, the strength of.
To overcome in battle or contest.