denature vs refine

denature

verb
  • To take away a natural characteristic or inherent property of (a thing or a person). 

  • To combine fissile material with nonfissile material in order to prevent its use in an atomic weapon. 

  • To alter its original form or state, especially of a protein, by heat, acidity etc. 

  • To add something to (alcohol) that makes it unsuitable for consumption but leaves it suitable for most other purposes. 

refine

verb
  • To improve in accuracy, delicacy, or excellence. 

  • To become pure; to be cleared of impure matter. 

  • To purify of coarseness, vulgarity, inelegance, etc.; to polish. 

  • To make nice or subtle. 

  • To purify; reduce to a fine, unmixed, or pure state; to free from impurities. 

How often have the words denature and refine occurred in a corpus of books? (source: Google Ngram Viewer )