To severely disrupt the well-being of (a person); ruin.
To sing a song poorly.
To put down or euthanize.
To remove data.
To exhaust duly and thus recreate or build up.
To penetrate sexually in an aggressive way.
To damage beyond use or repair.
To defeat soundly.
To neutralize, undo a property or condition.
To greatly demoralize, to cause to suffer intense grief or dismay
To ruin many or all things over a large area, such as most or all buildings of a city, or cities of a region, or trees of a forest.
To destroy a whole collection of related ideas, beliefs, and strongly held opinions.
To break beyond recovery or repair so that the only options are abandonment or the clearing away of useless remains (if any) and starting over.