That which displeases; cause of irritation or annoyance; offence; injury.
A feeling of being displeased with something or someone; dissatisfaction; disapproval.
A state of disgrace or disfavour.
The state or quality of being irritable; quick excitability
A natural susceptibility, characteristic of all living organisms, tissues, and cells, to the influence of certain stimuli, response being manifested in a variety of ways.
A condition of morbid excitability of an organ or part of the body; undue susceptibility to the influence of stimuli.