To exhaust, to tire out.
To kill or end.
To damage or injure.
To release from one's grasp; to go from a state of holding on to a state of no longer holding on.
To dismiss from employment.
To ignore (a comment, etc.).
To emotionally disengage or to distract oneself from a situation.
To fail to maintain a standard of appearance, behavior, or performance.
Used other than figuratively or idiomatically: see let, go.
To gain weight