Something or someone disagreeable, dispiriting or depressing; a killjoy.
A livestock animal that has collapsed.
A negative drug trip.
A form of industrial action in which workers down tools and refuse to work.
A drug that has depressant qualities.
Great unhappiness; extreme pain of body or mind; wretchedness; distress; woe.
A bodily ache or pain.
poverty.
Cause of misery; calamity; misfortune.