To bring into existence (a situation, quality, result etc.); to give rise to, cause, create.
To assume form; to come into existence; to be caused or produced.
To give existence to, to produce (living creatures).
To endow with gender; to create gender or enhance the importance of gender.
To disappoint or defeat; to vex by depriving of something expected or desired.
To cause stress or annoyance.
To hinder or thwart.
ineffectual; useless; fruitless.