To manipulate in order to gain something for oneself.
To adjust the position, as of an electronic device, in order to provide better reception or signal.
To manipulate an object, especially in a nervous or restless manner.
To trick.
To sexually stimulate a person or a person's erogenous zone.
Used other than figuratively or idiomatically: play with.
To fiddle with; make small adjustments to, for example to something mechanical in order to improve its performance.