The base after home plate in a counter-clockwise path around a baseball infield.
Completion of the first phase of an activity.
Kissing, regarded as the first phase of a sexual relationship.
The betting spot located immediately to the left of the dealer, which is first to receive cards and first to act.
The short distance that a player stands away from their current base.
The first batter in the batting order.
The first batter of an inning.
To be the first batter of an inning.
To be the first of any set, especially the first person in a group to speak; to launch or begin something by speaking.
Used other than figuratively or idiomatically: see lead, off.