Most importantly.
In front, prominently forward.
First in time.
Positioned in front of (all) others in space, most forward.
Coming before (all) others in time.
Closest to the bow.
Of the highest rank or position; of the greatest importance; of the highest priority.
In contrast.
How ever: an emphatic form of how, used to ask in what manner.
To whatever degree or extent.
Nevertheless; yet, still; in spite of that.
In any way that one likes or chooses; in a haphazard or spontaneous way.
In any way in which.
Regardless of the way in which.
But, yet, though, although.