Mental or bodily distress.
Something that disturbs one’s comfort; an annoyance.
To cause annoyance or distress to.
An abnormal skin sensation similar to that of insects crawling over or within the skin; a tactile hallucination involving such a sensation. A common side-effect of substance abuse, it can also be experienced with high fever, menopause, skin cancer, diabetic neuropathy, or herpes zoster.