Distressed or causing distress, for example through complexity.
Furnished, equipped.
Loaded up or charged with; accompanied by; entailing.
Laden.
Two bucketfuls (of water).
A load; a burden.
To load (a ship, cargo etc.).
Causing discomfort or constraint
I've been uneasy about your friend ever since I met him. Are you sure we can trust him?
Not easy; difficult.
Restless; disturbed by pain, anxiety
Not easy in manner; constrained