Drunk; wasted; incredibly intoxicated (not necessarily with alcohol).
Damaged; poorly manufactured; injured.
In disarray or dishevelment (emotionally or otherwise).
Misconstrued or misunderstood; taken the wrong way
Morally reprehensible; clearly and grossly objectionable.
In a screwed up or messed up manner; (by extension) under the influence of alcohol or drugs.
All wrong; mistaken; taken the wrong way
Intoxicated by eating locoweed.
Crazy.
To render insane.
To poison with the loco plant; to affect with locoism.
A certain species of Astragalus or Oxytropis, capable of causing locoism.
A locomotive.
A direction in written or printed music to be returning to the proper pitch after having played an octave higher or lower.