Drunk; wasted; incredibly intoxicated (not necessarily with alcohol).
Damaged; poorly manufactured; injured.
In disarray or dishevelment (emotionally or otherwise).
Misconstrued or misunderstood; taken the wrong way
Morally reprehensible; clearly and grossly objectionable.
In a screwed up or messed up manner; (by extension) under the influence of alcohol or drugs.
All wrong; mistaken; taken the wrong way
Very intoxicated from alcohol or recreational drugs.
Destroyed, usually in an accident; damaged to the point of unusability.
Having been put in a dreadful or embarrassing situation; can range from being pwned in a game to being utterly defeated in an argument or publicly shamed with a stinging insult.