manuscript; any nonprinted or handwritten text
a book or document written by hand
A book, composition or any other document, written by hand (or manually typewritten), not mechanically reproduced.
A single, original copy of a book, article, composition etc, written by hand or even printed, submitted as original for (copy-editing and) reproductive publication.
Handwritten, or by extension manually typewritten, as opposed to being mechanically reproduced.