To greatly demoralize, to cause to suffer intense grief or dismay
To ruin many or all things over a large area, such as most or all buildings of a city, or cities of a region, or trees of a forest.
To destroy a whole collection of related ideas, beliefs, and strongly held opinions.
To break beyond recovery or repair so that the only options are abandonment or the clearing away of useless remains (if any) and starting over.
To treat (a person) badly; to subject to hardships.
Difficulty or trouble; hard times.
A burden, a source of difficulty that could impose a barrier.