To treat (a person) badly; to subject to hardships.
Difficulty or trouble; hard times.
A burden, a source of difficulty that could impose a barrier.
To embarrass, to humiliate. To injure one's dignity.
To grant in mortmain.
To discipline (one's body, appetites etc.) by suppressing desires; to practise abstinence on.
To lose vitality.
To be subdued.
To gangrene.