To treat (a person) badly; to subject to hardships.
Difficulty or trouble; hard times.
A burden, a source of difficulty that could impose a barrier.
To treat maliciously; to try to hurt or thwart.
To fill with spite; to offend; to vex.
Ill will or hatred toward another, accompanied with the desire to unjustifiably irritate, annoy, or thwart; a want to disturb or put out another; mild malice
Notwithstanding; despite.