That which is despaired of.
That which causes despair.
Loss of hope; utter hopelessness; complete despondency.
To be hopeless; to have no hope; to give up all hope or expectation.
To cause to despair.
detriment; misfortune.
physical injury; hurt; damage
That which causes injury, damage, or loss.
emotional or figurative hurt
To cause injury to another; to hurt; to cause damage to something.