To spoil one's good mood or to annoy one.
To annoy or irritate.
To remove the spleen, or, by extension, to gore.
To excise or remove.
To complain; to rail; to vent one's spleen.
A fit of immoderate laughter or merriment.
In vertebrates, including humans, a ductless vascular gland, located in the left upper abdomen near the stomach, which destroys old red blood cells, removes debris from the bloodstream, acts as a reservoir of blood, and produces lymphocytes.