To cause havoc.
To pillage.
Widespread devastation and destruction.
Mayhem.
A cry in war as the signal for indiscriminate slaughter.
To ruin utterly and catastrophically, to cause to end in disaster.
The aftermath of a train crash.
A disaster, especially one which is large in scale and readily seen by public observers.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.