A road with no exit; a cul-de-sac.
A deadlock or stalemate situation in which no progress can be made.
The aftermath of a train crash.
A disaster, especially one which is large in scale and readily seen by public observers.
Someone (especially a woman) who is unbalanced and considered a mess, a disaster, one who is suffering personal ruin.
To ruin utterly and catastrophically, to cause to end in disaster.