To denounce as harmful.
To blame for ills.
To be insensitive, insolent, or rude to (somebody); to affront or demean (someone).
Something causing disease or injury to the body or bodily processes; the injury so caused.
Something that causes offence (for example, by being of an unacceptable quality).
Action or form of speech deliberately intended to be rude; (countable) a particular act or statement having this effect.