To be insensitive, insolent, or rude to (somebody); to affront or demean (someone).
Something causing disease or injury to the body or bodily processes; the injury so caused.
Something that causes offence (for example, by being of an unacceptable quality).
Action or form of speech deliberately intended to be rude; (countable) a particular act or statement having this effect.
To annoy, irritate.
To toss back and forth; to agitate; to disquiet.
To twist, to weave.
To cause (mental) suffering to; to distress.