To defeat soundly.
To sing a song poorly.
To put down or euthanize.
To remove data.
To exhaust duly and thus recreate or build up.
To penetrate sexually in an aggressive way.
To damage beyond use or repair.
To severely disrupt the well-being of (a person); ruin.
To neutralize, undo a property or condition.
To reject something.
No.
Nothing; nix; often in the phrase "ixnay on ...", indicating something that must not be mentioned, often in Pig Latin