keynote vs upshot

keynote

• The main theme of a speech, a written work, or a conference. 

• The note on which a musical key is based; the tonic. 

• A speech that sets the main theme of a conference or other gathering; a keynote speech or keynote address. 

• To deliver a speech that sets the main theme of a conference or other gathering. 

upshot

• A concise summary. 

• The final result, or outcome of something. 

• A positive aspect or consequence, often either unexpected or in contrast to other negative aspects.