Of a problem, that continues over an extended period of time.
Good, great; "wicked".
Inveterate or habitual.
Very bad, awful.
Prolonged or slow to heal.
Of a person, suffering from an affliction that is prolonged or slow to heal.
Extremely serious.
A condition of extended duration, either continuous or marked by frequent recurrence. Sometimes implies a condition which worsens with each recurrence, though that is not inherent in the term.
Marijuana, typically of high quality.
A person who is chronic, such as a criminal reoffender or a person with chronic disease.
Extending for the entire duration of life.