To reduce.
To cause to fall down, e.g. in an accident.
To make something, especially something flying, fall to the ground, usually by firing a weapon of some kind.
To make someone feel bad emotionally.
To make a ruler lose their position of power.
To cause an opponent to fall after a tackle.
To humble.
To cease to behave in a consistent and/or rational manner.
To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
Used other than figuratively or idiomatically: see lose, plot.