To be neglected; to make little progress, be unsuccessful.
To pine away in longing for something; to have low spirits, especially from lovesickness.
To live in miserable or disheartening conditions.
To lose strength and become weak; to be in a state of weakness or sickness.
To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
Used other than figuratively or idiomatically: see lose, plot.
To cease to behave in a consistent and/or rational manner.