To behave irrationally or to lose one's self-control, especially in a distressing situation or as a result of falling in love.
To suffer decapitation.
To be killed, usually in a gruesome manner.
To be dismissed from a job.
To cease to behave in a consistent and/or rational manner.
To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
Used other than figuratively or idiomatically: see lose, plot.