To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
Used other than figuratively or idiomatically: see lose, plot.
To cease to behave in a consistent and/or rational manner.
To lose firmness, elasticity, vigor, or a thriving state; to sink; to droop; to flag; to bend; to yield, as the mind or spirits, under the pressure of care, trouble, doubt, or the like; to be unsettled or unbalanced.
To cause to bend or give way; to load.
To wear one's trousers so that their top is well below the waist.
To pull down someone else's pants.
To loiter in walking; to idle along; to drag or droop heavily.
To sink, in the middle, by its weight or under applied pressure, below a horizontal line or plane.
To lean, give way, or settle from a vertical position.
The state of sinking or bending; a droop.
The difference in height or depth between the vertex and the rim of a curved surface, specifically used for optical elements such as a mirror or lens.
The difference in elevation of a wire, cable, chain or rope suspended between two consecutive points.