To lose sight of an important objective or principle; to act contrarily to one's own interests through concentrating on relatively unimportant matters.
Used other than figuratively or idiomatically: see lose, plot.
To cease to behave in a consistent and/or rational manner.
To behave in an extremely erratic or irrational manner; to lose one's mind.
To become extremely emotional or excitable; to lose control of one's emotions.
To cause to become extremely emotional or excitable.
A chaotic or crazy episode.