Madness or insanity.
A progressive decline in cognitive function due to damage or disease in the brain beyond what might be expected from normal aging. Areas particularly affected include memory, attention, judgement, language and problem solving.
A delusion in which one believes oneself to be a wolf or other wild animal.
The state of being a person who can shapeshift between the form of a human being and an animal, whether or not it is a wolf.
The state of being a lycanthrope (or werewolf), a person who can shapeshift between the form of a human being and a wolf, often said to happen involuntarily during a full moon; werewolfdom.