Used other than figuratively or idiomatically: see make, it.
To have sexual intercourse; do it.
To succeed in doing something, for example in reaching a place, going somewhere, attending an event, arriving in time for something, adding to one's schedule or itinerary, or in getting where one wants to be in one's life or career, which sometimes means becoming or wanting to become successful (succeed in a big way) or famous.
To succeed in surviving, in living through something.